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On its own, spironolactone is only a weak diuretic because its effects target the distal nephron (collecting tubule), where urine volume can only be slightly modified; but it can be combined with other diuretics to increase efficacy.
Baclofen (brand names Kemstro and Lioresal) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is under investigation for the treatment of alcoholism. It is an agonist specific to mammalian, but not fruit fly (Drosophila) GABAB receptors.Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. |
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